Amazon is expected to sign up for a 360,000sq ft warehouse at Haydock, close to junction 23 of the M6 motorway.
The online retail giant is in talks to take a new fulfilment centre in a deal with developer Bericote.
Bericote has applied for reserved matters planning approval for a 360,000sq ft unit and a 476,000sq ft unit at the 1.4 million sq ft development.
Amazon have remained consistently active in the UK warehousing sector. Only last month they signed up for a 1.5m SF fulfilment centre in Darlington in a deal with Manchester's db symmetry.